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Malaria patients in Southeast Asia were found to be thiamin deficient more frequently than non-infected individuals (24, 25)

Fourth, the use of pseudo-observations at zero dose, while methodologically justified to stabilize model behavior at the lower boundary, represents a modeling assumption that may influence extrapolation outside the observed dose range

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mild irritation or transient redness is the most commonly reported issue

Data availability Data and analysis code are available in supplementary information